Illustration, not a product photo.
Akkermansia muciniphila, sold in the US mainly by Pendulum.
124 owner comments (49 with a clear rating) from r/Microbiome, r/IBS, r/SIBO, r/Constipation, November 2025 to October 2026. Top 100% of the 36 rated supplements.
Value is not rated: the example products differ too much in dose to compare cost fairly. How we score.
Akkermansia (Pendulum) is rated below most supplements we track: 3.3/5. Of 49 rated owner comments, 37 were positive, 1 mixed and 11 negative; 8 mention an unwanted effect. People talk most about bloating & gas and side effects.
Reddit comments are self-reported and unverified. They tell you what people noticed, not whether a supplement works or is safe for you.
Here is how to read a probiotic label by strain. See what owners report about gut supplements for SIBO. Reddit owners also rank supplements by cramping reports.
Supplements can interact with medicines. Talk to a doctor or pharmacist first, especially if you are pregnant, take prescription medicine, or have red-flag symptoms. See supplement safety and interactions.
| Context | Rated owner comments | Positive | Negative | Unwanted effects |
|---|---|---|---|---|
| Bloating & gas | 14 | 10 | 3 | 2 |
| SIBO | 8 | 5 | 3 | 1 |
| IBS-D & loose stools | 4 | 3 | 1 | 0 |
| Stool form | 3 | 2 | 1 | 1 |
| Pain & cramping | 3 | 0 | 3 | 2 |
4/5“Akkermansia is primarily a microbe implicated in its interactions with the mucosal layer, because it helps to maintain the turnover of the mucosa by metabolizing the mucosa.”
4/5 Bloating & gasUrgency & loose stools“coli, Bilophila and LPS, while also feeding Akkermansia.”
4/5 Bloating & gas“Yep — Pendulum is the most talked‑about because it was one of the first *live* Akkermansia products, but there *are* other options people are trying now.”
2/5 Regularity“I have Crohn's disease, I've tried all kinds of probiotics with no effect but akkermansia muciniphilia and butyrate (postbiotic) have an unmistakable positive effect on my bms.”
1/5 Bloating & gasPain & cramping“Akkermansia absolutely fucked me up. I took it for 3 days before I stopped because of how terrible it made me feel. Some of the worst bloating I’ve had, stomach aches, messed with my appetite, etc.”
2/5“Akkermansia gave me a noticeable bump in satiety and steadier blood sugar feelings after meals, but it was not a miracle and it seemed to work best when I tightened up fiber and polyphenols at the same time (berries, pomegranate, green tea).”
4/5“Try the Akkermansia probiotic. If your gut lining is impaired like mine, this helped me tremendously.”
4/5“Adding akkermansia improved so many things for me.”
3/5“I have EDS and what used to be awful IBS and am on Zepbound which slows my motility even more and aside from low FODMAP the one thing that helped me the most was the probiotic akkermansia muciniphilia that my IM doc put me on.”
4/5“Live akkermansia fucks me up but the pasteurized version works great for me”
4/5“I recently started Pendulum’s glucose control (haven’t noticed a difference yet) with akkermansia.”
1/5“I think its all balance at the end of the day, too much akkermansia is just as bad as none(?) maybe.”
4/5“I’d recommend that everyone do a stool test first so you know whether something like Akkermansia is actually right for you.”
4/5“I have had a 99% better life now that I take the Akkermansia probiotic.”
4/5“That works well for me too)Akkermansia sold on Amazon.”
4/5“But so far (5 months) taking the Akkermansia probiotic has helped so much more for me.”
4/5“I discovered Akkermansia single strain, Butyrate (single strain) & Rituals 3-1 Probiotics (3 strains).”
5/5“Try Akkermansia probiotic. It worked wonders for me!”
1/5 Side effects“I tried akkermansia a few months ago. I got about halfway through the bottle before I had to stop taking it. It was making me feel absolutely terrible and nauseous.”
4/5“I take both Akkermansia & Rituals 3/1 Synbiotic probiotics.”
4/5“What helped me was Akkermansia probiotic.”
4/5 Bloating & gas“I’ve been using a high-purity **Akkermansia** supplement for a while now, and it’s helped my bloating and digestion feel more stable overall:…”
4/5“Akkermansia also made a difference for me.”
2/5 Urgency & loose stools“I tried akkermansia from pendulum at the rate of two capsules per day as suggested.”
4/5“I haven’t tested (because I don’t really have any GI symptoms) but I started Pendulum Akkermansia to help with blood sugar (not diabetic either, just have blood sugar dysregulation - reactive hypoglycemia) But I noticed within 6 weeks of…”
4/5 Bloating & gas“Taking a high-purity **Akkermansia** supplement has helped me feel more regulated, less bloated, and I’ve seen more stable blood sugar on my CGM too.”
4/5 Side effectsStopped working“That’s interesting — I’ve had a similar experience with **Akkermansia muciniphila**.”
4/5 Bloating & gas“Diet and prebiotics definitely help the early stages, but the keystone bacteria like **Akkermansia muciniphila** seem to make a noticeable difference for long-term gut stability.”
4/5 Bloating & gas“Akkermansia muciniphila can support the gut lining and metabolism, but over-colonization in a disrupted gut environment can stress the mucus layer, as that study shows.”
2/5 Side effects“I started Pendulum Akkermansia about a a week ago and my appetite is back with a vengeance.”
4/5“(Note I replaced Thorne's FiberMend with GutFuel so there is something specific about the polyphenol / fiber blend + Akkermansia that works for me in a way that other fiber supplements did not.”
4/5 Regularity“Akkermansia via Pend͏ulum felt like a “subtle but real” thing for me, more regular digestion after a week or two, then it faded a month or two after stopping, which lines up with folks saying it does not really stick around.”
2/5 Side effects“I have been taking the Pendulum Akkermansia for a month every morning.”
4/5“I also tried this Next-Microbiome Boost Synergy with Akkermansia, all i can say is that it really helped me.”
4/5 Bloating & gasStool form“One thing worth looking into is Akkermansia muciniphila, it specifically targets gut lining integrity which could tie into a lot of what you're experiencing.”
These are examples of Akkermansia (Pendulum) products sold on Amazon. They are not ranked by Reddit and the score above is for the ingredient, not a specific product. Check the label for dose and other ingredients.
Published studies (we list them so you can read the evidence yourself; inclusion is not an endorsement):
Across 124 Reddit comments from people who say they have used it, 37 of 49 rated comments were positive and 11 negative, for a GutVerdict score of 3.3/5. These are self-reported experiences, not clinical evidence.
8 of 49 rated owner comments (16%) describe an unwanted effect such as gas, bloating or an upset stomach. Check the safety notes on this page and ask a doctor or pharmacist before starting.
Most rated owner comments come from people who struggle with bloating and gas (14 comments, 10 positive).
No. The score summarizes Reddit owner comments only. Factual statements on this page link to NIH or PubMed sources, and nothing here is medical advice.
“I started taking spore based probiotics lately because it's supposed to help with the health of the valve and it do believe it is helping.”
What owners report →
“I've tolerated taking Florastor 3x a day during antibiotics.”
What owners report →
“One one of probiotics I was taking, LGG get rid of bilophila, but increased desulfovibrio.”
What owners report →Last updated 2026-11-03. Mentions scanned: 598 in 337 threads.