Illustration, not a product photo.
Bifidobacterium longum 35624 (formerly called B. infantis 35624), the strain in Align and Alflorex.
77 owner comments (47 with a clear rating) from r/IBS, r/SIBO, r/Microbiome, r/Constipation, November 2025 to October 2026. Top 98% of the 36 rated supplements.
Value is not rated: the example products differ too much in dose to compare cost fairly. How we score.
B. longum 35624 (Align) is rated below most supplements we track: 3.4/5. Of 47 rated owner comments, 33 were positive, 3 mixed and 11 negative; 5 mention an unwanted effect. People talk most about bloating & gas and side effects.
Reddit comments are self-reported and unverified. They tell you what people noticed, not whether a supplement works or is safe for you.
Read why probiotic strains are not interchangeable. People also compare supplements for IBS-C and constipation on Reddit. Compare the top-rated options for loose stools by symptom.
Supplements can interact with medicines. Talk to a doctor or pharmacist first, especially if you are pregnant, take prescription medicine, or have red-flag symptoms. See supplement safety and interactions.
| Context | Rated owner comments | Positive | Negative | Unwanted effects |
|---|---|---|---|---|
| SIBO | 17 | 10 | 6 | 2 |
| Bloating & gas | 14 | 10 | 2 | 2 |
| IBS-C & constipation | 12 | 7 | 5 | 1 |
| IBS-D & loose stools | 11 | 7 | 3 | 1 |
| After antibiotics | 6 | 6 | 0 | 1 |
| Pain & cramping | 6 | 5 | 1 | 1 |
| Stool form | 3 | 1 | 2 | 0 |
4/5 Bloating & gas“In addition it said that Align is meant for people with IBS-D which I never had.”
4/5“I eventually took five Align pills per day to control the symptoms.”
4/5“But as someone with mixed IBS, alflorex helped me a lot.”
2/5 Bloating & gas“I've had a similar experience with Align probiotics.”
2/5“any probiotic type food or supplement does NOT work for me, the only probiotic I can tolerate is b longum 35624”
3/5“For me personally, probiotics and fermented things all made me feel much worse, except for Align.”
4/5 Pain & crampingSide effects“Im going to buy Align probiotics to see if that helps me.”
4/5 Fast-actingUrgency & loose stools“He recommended Align Probiotics, a single species probiotic.”
5/5 Bloating & gasGentle“My GI recommended align probiotic and it’s been amazing !”
4/5“I am using alflorex for the last 3ish months and it helped me very much at first but now it’s losing its effect.”
4/5“I also added Align - probiotic, which has helped him, but may not help everyone - depends on what microbes you are missing.”
1/5“Seed, Align, and various brands I find at my pharmacy (can’t remember their names).”
2/5 Stool form“because they have become like a vitamin for my stomach so why not buy in bulk 😂😂…..now I also have added align probiotics and that backfired a bit…..def not constipated taking the align…..so I am spacing the, further apart so I can have…”
3/5“I thought I got some relief from it when I stopped taking Align probiotic daily.”
4/5 Regularity“But I’m here to say that I read this and tried Align.”
4/5 CostFast-acting“I've been on Alflorex for serveral years and I'm considering quitting.”
2/5“I tried Align probiotic since my gastro suggested it, but it seemed to either aggrivate or not help my stomach at the time so I stopped taking it after only a few doses.”
4/5 Bloating & gas“I have recently tried alflorex dual action (in the uk) sold under different names in other countries.”
4/5“I tried alflorex for 3 months and at first it helped me a lot.”
4/5“Cold packs, lots of water and Align gummies helped me.”
4/5 Bloating & gasStool form“Recently, I started taking a B-complex vitamin and Align probiotic.”
4/5 Bloating & gas“I use something similar to Align. It helps with the digestive issues like the gas because your current microbiome is eating up all the food sitting in your stomach and releasing gas. Hang in there.”
4/5 Gentle“Be gentle with your tummy, and I honestly cant recommend the Align probiotics enough (I took the Advanced ones)”
4/5“Align probiotic really helped me on a 3 day road trip 3 casual restaurants and had no ibs because I took one a day at dinner you can get it at Costco or any drug store”
2/5“I tried Align and it didn't help.”
4/5“I did as the gastro said - stayed away from gluten whilst I started the probiotics (I took the Advance Align ones).”
1/5 Side effects“I think Align probiotics made my sibo worse.”
1/5 Side effects“I get terrible side effects from Align and can’t take it”
4/5“Florastor and Align are the two probiotics recommended by my GI doctor for if I ever have to take antibiotics again (I've had c.”
4/5 Bloating & gas“I found the most benefit for bloating and speeding up digestion by taking Align for bloating probiotic.”
4/5“I’m currently taking Align, which is an over-the-counter probiotic my GI doctor recommended.”
4/5“align probiotics helps with SIBO. I take code of cultures. either works.”
2/5 CostUrgency & loose stools“I used to take Align (based on the gastroenterologist’s recommendation) for my GI system.”
4/5“I asked it to recommend probiotics and it recommended taking two(align 5x extra strength 35624 and saccharomyces boulardii).”
4/5“Try Alflorex - it’s worked for me.”
These are examples of B. longum 35624 (Align) products sold on Amazon. They are not ranked by Reddit and the score above is for the ingredient, not a specific product. Check the label for dose and other ingredients.
Published studies (we list them so you can read the evidence yourself; inclusion is not an endorsement):
Across 77 Reddit comments from people who say they have used it, 33 of 47 rated comments were positive and 11 negative, for a GutVerdict score of 3.4/5. These are self-reported experiences, not clinical evidence.
5 of 47 rated owner comments (11%) describe an unwanted effect such as gas, bloating or an upset stomach. Check the safety notes on this page and ask a doctor or pharmacist before starting.
Most rated owner comments come from people in r/SIBO and others who mention SIBO (17 comments, 10 positive).
No. The score summarizes Reddit owner comments only. Factual statements on this page link to NIH or PubMed sources, and nothing here is medical advice.
“I started taking spore based probiotics lately because it's supposed to help with the health of the valve and it do believe it is helping.”
What owners report →
“I've tolerated taking Florastor 3x a day during antibiotics.”
What owners report →
“One one of probiotics I was taking, LGG get rid of bilophila, but increased desulfovibrio.”
What owners report →Last updated 2026-11-03. Mentions scanned: 231 in 189 threads.