Gut-lining & amino acids
L-glutamine
4.0 (456 owner comments)
Bloating & gasSide effects
“My condition improved when I started to take Glutamine in the morning and one banana before bed.”
What owners report →Medical disclaimer: GutVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you are pregnant, take medicines, or have a medical condition. New, severe or worsening symptoms (such as blood in the stool, weight loss, fever, or night-time symptoms) need a doctor, not a supplement. Full disclaimer.
Gut-lining & amino acids · capsules
Zinc carnosine: What People With IBS Report on Reddit
Illustration, not a product photo.
A zinc and L-carnosine complex (polaprezinc).
3.7 GutVerdict score
108 owner comments (37 with a clear rating) from r/SIBO, r/Microbiome, r/IBS, r/Constipation, November 2025 to October 2026. Top 56% of the 36 rated supplements.
Owner sentiment3.7
Recommendations2.4
Tolerability4.6
ValueNot rated
Value is not rated: the example products differ too much in dose to compare cost fairly. How we score.
The short version
Zinc carnosine is rated about average among the supplements we track: 3.7/5. Of 37 rated owner comments, 30 were positive, 1 mixed and 6 negative; 3 mention an unwanted effect. People talk most about side effects and fast-acting.
Reddit comments are self-reported and unverified. They tell you what people noticed, not whether a supplement works or is safe for you.
Reddit owners also rank supplements by SIBO reports. There is a separate ranking of what people with IBS-C and constipation rate highest. Reddit owners also rank supplements by bloating reports.
What it is
- A small 2007 study looked at zinc carnosine and small-bowel permeability.[PubMed]
Safety and interactions
- Long-term high zinc intake can cause copper deficiency; the adult upper limit for zinc is 40 mg a day from all sources.[NIH Office of Dietary Supplements]
Supplements can interact with medicines. Talk to a doctor or pharmacist first, especially if you are pregnant, take prescription medicine, or have red-flag symptoms. See supplement safety and interactions.
Reports by symptom
| Context | Rated owner comments | Positive | Negative | Unwanted effects |
|---|---|---|---|---|
| SIBO | 25 | 18 | 6 | 3 |
| Bloating & gas | 7 | 5 | 1 | 0 |
| IBS-C & constipation | 5 | 3 | 1 | 1 |
| IBS-D & loose stools | 3 | 3 | 0 | 0 |
| After antibiotics | 3 | 2 | 1 | 0 |
What Reddit owners say
Commonly praised
- Fast-acting: 3 owner comments
- Urgency & loose stools: 2 owner comments
- Bloating & gas: 1 owner comment
Common complaints
- Side effects: 3 owner comments
- Bloating & gas: 1 owner comment
5/5“Yes...zinc carnosine has been a gamechanger for me.”
4/5“Lately, I've been feeling a bit better by taking Astralagus extract, black goat extract, L-glutamine, Kidney supplements, Zinc carnosine.”
5/5 Fast-actingUrgency & loose stools“Nutricost Zinc Carnosine works for me...”
2/5 Side effects“Repair phase was GI revive but something in it gave me heartburn and nausea, so now I do the zinc carnosine and straight glutamine and it's been working well.”
1/5“For me it is Zinc (Zinc Carnosine is the worst).”
+25 more owner comments
4/5 Bloating & gas“I still have SIBO - I started taking l glutamine & zinc carnosine ~6 weeks ago.”
4/5“I took a bunch of zinc carnosine during my glp1 run for other reasons.”
5/5“So carnivore diet, as well as zinc carnosine and l glutamine were the best for me in terms of minimising these symptoms and smelling clean.”
4/5“\- I noticed changes after taking zinc carnosine (especially helped fullness - I feel hunger sooner)”
4/5“Zinc Carnosine helped me tremendously.”
4/5“I take ginger root, zinc carnosine and mago7 but I haven’t found comfort or like wow I feel way better.”
4/5“zinc carnosine, magnesium, and l-glutamine helped me after an extreme case of food poisoning.”
2/5 Side effects“He also made me take 2 full dosages of zinc carnosine which made me nauseous which he doesn’t say in his post.”
4/5“I used zinc carnosine for 3months for gastritis (mixed with anemia).”
4/5“And as for supplements that have helped me… L glutamine and zinc carnosine have been incredible.”
4/5“I've also used zinc carnosine and had good results.”
4/5“Thought I would share this here and also ask you why you recommended to OP to take Zinc Carnosine.”
4/5“I’ve noticed my greatest relief when I started taking zinc carnosine.”
2/5 Bloating & gas“I tried Zinc Carnosine, stay with gas day and night.”
4/5“I've tried zinc carnosine and dont know if I noticed a difference.”
3/5“PPis make it 100 times worse, mastic gum helps … like chewing it after meals, I’ve tried zinc carnosine and also berberine which just makes me want to poop and just feels ick, I do have constipation and was diagnosed years ago with gerd…”
2/5 Side effects“I don't recommend the garlic and oregano since it gave me gastritis which I fixed with zinc carnosine.”
4/5“I am currently taking only Zinc carnosine and I feel like I can handle trigger food way better.”
4/5“i am thinking to start refaximin but after your advise i think its better to do zinc carnosine, slippery elm first.”
4/5“It seems to calm down the inflammation in my gut way better than zinc carnosine or glutamine.”
4/5 Cost“I would say the things that helped most were probiotics, fermented foods (like sauerkraut), zinc carnosine supplements, and working on my mental health.”
2/5“I’ve tried b1 (gives me anxiety) maybe cuz of sulphur…I’ve tried D, C, zinc and zinc carnosine, nothing helps.”
4/5“I took it in conjunction with Zinc Carnosine and I believe it really helped.”
4/5“I don’t know if this will help but I’m starting on zinc carnosine.”
4/5“Colostrum + zinc-carnosine +probiotics worked for me.”
Example products
These are examples of Zinc carnosine products sold on Amazon. They are not ranked by Reddit and the score above is for the ingredient, not a specific product. Check the label for dose and other ingredients.
Example product · not Reddit-scored
Doctor's Best PepZin GI, Zinc-L-Carnosine Complex, Vegan
$22.99 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Example product · not Reddit-scored
Pure Encapsulations Peptic-Care (Zinc-L-Carnosine), 60 Capsules
$68.00 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Research to read
Published studies (we list them so you can read the evidence yourself; inclusion is not an endorsement):
FAQ
What do people with IBS say about Zinc carnosine on Reddit?
Across 108 Reddit comments from people who say they have used it, 30 of 37 rated comments were positive and 6 negative, for a GutVerdict score of 3.7/5. These are self-reported experiences, not clinical evidence.
Do people report side effects with Zinc carnosine?
3 of 37 rated owner comments (8%) describe an unwanted effect such as gas, bloating or an upset stomach. Check the safety notes on this page and ask a doctor or pharmacist before starting.
Who talks about Zinc carnosine most?
Most rated owner comments come from people in r/SIBO and others who mention SIBO (25 comments, 18 positive).
Is Zinc carnosine scored on clinical evidence?
No. The score summarizes Reddit owner comments only. Factual statements on this page link to NIH or PubMed sources, and nothing here is medical advice.
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What owners report →Last updated 2026-11-03. Mentions scanned: 480 in 364 threads.